Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rej

• 作 者: Ming-Li Yin Hong-Li Song Yang
• 机 构: TianjinFirstCentralHospitalClinicInstitute,DepartmentofOrganTransplantation,DepartmentofOrganTranspl
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2017年22期
• 关键词: 骨头髓间充质的干细胞 CXCR3 HO-1 小肠移植 拒绝 Bone marrow mesenchymal stem cells CXCR3 HO-1 S
• 基金项目: Supported by The National Natural Science Foundation of China,No.81670574,No.81441022 and No.81270528,The Natural Science Foundation of Tianjin,China,No.08JCYBJC08400,No.11JCZDJC27800 and No.12JCZDJC2

AIM To investigate whether bone marrow mesenchymal stem cells(BMMSCs) modified with the HO-1 and CXCR3 genes can augment the inhibitory effect of BMMSCs on small bowel transplant rejection.METHODS Lewis rat BMMSCs were cultured in vitro. Thirdpassage BMMS