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目的:分析导致结核性胸膜炎患者出现多种不良反应的可能抗痨药物与解决方案。方法:临床药师通过查阅文献并结合患者病情,分析导致患者出现不良反应的可能抗痨药物。结果:患者的药物热可能由异烟肼引起;全身皮疹可能由乙胺丁醇引起;肝损可能由利福平与吡嗪酰胺合用导致;在临床药师建议下对患者的治疗方案改为莫西沙星与利福喷丁联用抗结核治疗,治疗多日无明显不良反应发生。结论:临床药师以专业特长参与临床治疗,促进合理用药,提高药物治疗水平。
OBJECTIVE: To analyze possible anti-tuberculosis drugs and solutions that lead to a variety of adverse reactions in patients with tuberculous pleurisy. METHODS: Clinical pharmacists reviewed the literature and combined the patient’s condition to analyze the possible anti-tuberculosis drugs that cause adverse reactions in patients. RESULTS: The patient’s medical fever may be caused by isoniazid; the systemic rash may be caused by ethambutol; the liver damage may be caused by the combination of rifampicin and pyrazinamide; the treatment regimen for the patient is changed to Moxisab Star and rifapentine combined with anti-TB treatment, treatment for many days no significant adverse reactions. Conclusion: Clinical pharmacists participate in clinical treatment with professional expertise to promote rational use of drugs and improve the level of drug treatment.