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我院收治3例厚皮性骨膜病(Pachydermo-periostosis),报道如下.临床特征见附表.讨论本病由 Friedrich 于1868年首先报告,1935年Fouraine Solente 和 Gole 进行了详细描述,故又名 Fouraine-Solente-Gole 综合征.1948年 Vo-gue 命名为厚皮性骨膜病.本病原因不明,系隐性或不完全的显性基因遗传,在一个厚皮性骨膜病的父子身上发现有异常的 XYY 型染色体,董义光等报告1例,并检查患者父母亲和三个女儿共5人,仅父及一个女儿的胫腓骨有骨皮质轻度增厚,母亲染色体异常.本文仅1例染色体异常,故染色体检测对厚皮性骨膜病的家族遗传不起作用.
Three cases of Pachydermo-periostosis were treated in our hospital and are reported below. Clinical characteristics are listed in the attached table. DISCUSSION The disease was first reported by Friedrich in 1868 and was described in detail by Fouraine Solente and Gole in 1935, Fouraine-Solente-Gole syndrome .Vo-gue named psoriatic periarthritis in 1948. The cause of the disease is unknown, the Department of recessive or incomplete dominant gene inheritance, found in a thick skin periosteal father and son Abnormal XYY chromosomes, Dong Yiguang and other reports of 1 case, and check the patient’s parents and three daughters a total of 5, only the father and a daughter tibia and fibula slightly thickening of the cortical bone, mother chromosomal abnormalities only 1 case of chromosome Abnormal, so chromosomal testing on the thickness of the pericarditis family inheritance does not work.