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目前研究表明 ,白色脂肪组织 (WAT)、棕色脂肪组织 (BAT)、骨骼肌及心肌的脂蛋白脂酶 (LPL)在机体的脂质代谢中的作用各不相同 ,而各种影响因素对LPL的作用又表现出组织特异性。如胰岛素可刺激脂肪组织的LPL ,而儿茶酚胺在抑制WAT的LPL活性的同时可刺激骨骼肌、心肌及BAT的LPL。烟碱可增加心肌的LPL而饮酒可增加BAT的LPL活性 ,体育锻炼和生长激素可增加骨骼肌LPL活性。这些研究提示 ,有可能通过调节LPL的组织特异性表达以达到使机体肥胖或消瘦的目的
The current research shows that the roles of white adipose tissue (WAT), brown adipose tissue (BAT), skeletal muscle and myocardial lipoprotein lipase (LPL) vary in the body’s lipid metabolism, and various influencing factors have different effects on LPL The role of the organization showed specificity. Insulin, for example, stimulates LPL in adipose tissue, whereas catecholamine stimulates LPL in skeletal muscle, myocardium and BAT while inhibiting LPL activity in WAT. Nicotine increases myocardial LPL and alcohol can increase BAT LPL activity, physical exercise and growth hormone can increase skeletal muscle LPL activity. These studies suggest that it is possible to achieve the goal of obesity or emaciation by modulating the tissue-specific expression of LPL