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目的检测正常儿童血清中邻苯二甲酸二丁酯(DBP)和邻苯二甲酸-2-乙基己酯(DEHP)水平。方法选择上海市正常儿童作为研究对象,用气相色谱检测其血清中DBP、DEHP含量,作正常儿童血清DBP、DEHP浓度分布,以及DBP、DEHP不同年龄和性别水平分析。结果 310例血样中,110例可检出DBP,118可检出DEHP,全部样品中DBP的浓度范围为未检出～0.98ng/ml,P75为0.68ng/ml,95%上限为0.75ng/ml,男女检出率无差别,检出率在不同年龄组间存在差别。全部样品中DEHP的浓度范围为未检出～0.94ng/ml,P75为0.67ng/ml,95%上限为0.74ng/ml,男女检出率无差别,检出率在不同年龄组间存在差别,婴儿组的检出率明显低于其他组。结论正常儿童的血清DBP、DEHP浓度较低,DBP低于0.75ng/ml,DEHP低于0.74ng/ml。
Objective To detect the levels of dibutyl phthalate (DBP) and 2-ethylhexyl phthalate (DEHP) in normal children. Methods Normal children in Shanghai were selected as study subjects. The contents of DBP and DEHP in serum were determined by gas chromatography. The concentrations of serum DBP and DEHP in normal children and the different age and gender levels of DBP and DEHP were analyzed. RESULTS: Of the 310 blood samples, 110 were detected for DBP and 118 for DEHP. The concentration of DBP in all samples ranged from undetected to 0.98 ng / ml, P75 was 0.68 ng / ml, and the 95% upper limit was 0.75 ng / ml, the detection rate of men and women no difference, the detection rate in different age groups there are differences. The concentration of DEHP in all samples ranged from undetected ~ 0.94 ng / ml, P75 was 0.67 ng / ml, and the 95% upper limit was 0.74 ng / ml, with no difference between male and female detection rates, with a difference in detection rates between different age groups , The detection rate of infants was significantly lower than other groups. Conclusion Normal children have lower serum DBP and DEHP concentrations, DBP less than 0.75ng / ml and DEHP less than 0.74ng / ml.