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目的探讨射血分数保留心力衰竭(HFpEF)住院患者左心室射血分数(LVEF)与氮末端脑钠尿肽前体(NT-proBNP)水平的相关性。方法选取339例心力衰竭患者,按照欧洲心脏病学会心力衰竭指南分组,测定其NT-proBNP水平、生化指标及心脏多普勒超声参数,对测量结果进行相关性分析。结果 HFpEF患者LVEF与NT-proBNP水平无相关性(P>0.05)。在所有心力衰竭患者中,随着LVEF的降低,NT-proBNP水平明显升高,差异有统计学意义(r=-0.470,P<0.001)。结论在心力衰竭患者中,NT-proBNP水平会随着LVEF的降低明显升高,但HFpEF患者LVEF与NT-proBNP并无此规律可言,故在临床中不能单纯地以LVEF或NT-proBNP水平高低来判断HFpEF患者病情的严重程度及其预后。
Objective To investigate the relationship between left ventricular ejection fraction (LVEF) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in hospitalized patients with preserved ejection fractional heart failure (HFpEF). Methods 339 cases of heart failure patients were selected according to the guidelines of the European Society of Cardiology for Heart Failure. NT-proBNP levels, biochemical parameters and Doppler echocardiographic parameters were measured and the correlations were analyzed. Results There was no correlation between LVEF and NT-proBNP level in HFpEF patients (P> 0.05). In all patients with heart failure, the level of NT-proBNP was significantly increased with the decrease of LVEF (r = -0.470, P <0.001). Conclusion In patients with heart failure, NT-proBNP levels will be significantly increased with the decrease of LVEF, but LVEF and NT-proBNP in patients with HFpEF no such rules at all, it can not be simply in clinical LVEF or NT-proBNP levels High and low to determine the severity of HFpEF patients and prognosis.