皮肌炎/多发性肌炎患者血清Jo-1抗体检测的临床意义

• 作 者: 张素英 刘玉阁 纪岩文 崔平津
• 机 构: 天津医科大学总医院皮肤科,天津医科大学总医院神经内科
• 出 处: 临床皮肤科杂志
• 发表日期: 1997年02期
• 关键词: 多发性肌炎 皮肌炎 Jo-1 抗合成酶抗体 抗合成酶综合征 间质性肺病 合并恶性肿瘤 可提取性核抗原 抗体滴度 病人血清

应用免疫印迹技术测定５２例皮肌炎和多发性肌炎病人血清可提取性核抗原（ＥＮＡ）多肽抗体，其中Ｊｏ－１抗体的阳性率分别为１３．３％和３１．８％。１１例Ｊｏ－１抗体阳性病人中７２．７％起病较急，对类固醇治疗反应差，减药或停药易于复发；４５．５％伴发间质性肺病，５４．５％伴有Ｒａｙｎａｕｄ现象，６３．６％合并关节炎，３６．４％合并恶性肿瘤。４１例Ｊｏ－１抗体阴性病人上述合并症阳性率仅分别为９．８％、１７．１％、１９．５％和１４．６％。抗合成酶抗体可能是引起组织损伤的直接因素。

Western blotting was used to detect the serum extractable nuclear antigen (ENA) antibody in 52 cases of dermatomyositis and polymyositis. The positive rate of Jo-1 antibody was 13.3% and 31.8% respectively. 72.7% of the 11 patients with positive Jo-1 antibody developed acute onset, had poor response to steroid treatment and were easy to relapse after drug withdrawal or discontinuation; 45.5% with interstitial lung disease, 54.5% with Raynaud Phenomenon, 63.6% with arthritis, 36.4% with malignant tumors. The positive rate of the above 41 cases of Jo-1 antibody-negative patients were 9.8%, 17.1%, 19.5% and 14.6% respectively. Anti-synthase antibodies may be the direct cause of tissue damage.