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已知屋尘螨是诱发支气管哮喘(哮喘)的一个重要病因。但是接触螨的多少与哮喘的严重程度之间的量化关系仍不清楚。吸入内毒素能增加哮喘患者的气道反应性,增加肺泡灌洗液中的白细胞数。内毒索也存在于屋尘中,为观察哮喘患者接触屋尘后.内毒素是否将成为导致哮喘加重的一种因素,作者选择一组对屋尘螨过敏的易感者,让受试者接触屋尘螨,测定屋尘中的内毒素浓度,评价内毒素对哮喘严重程度的影响。
House dust mites are known to be an important cause of bronchial asthma (asthma). However, the quantitative relationship between the number of exposed mites and the severity of asthma remains unclear. Inhaling endotoxin increases airway responsiveness in asthmatic patients and increases the number of leukocytes in the alveolar lavage fluid. Endotoxin is also present in house dust, to see if endotoxin is a contributing factor to asthma exacerbation after asthma patients are exposed to house dust. The authors selected a panel of susceptible individuals who were allergic to house dust mites, Exposure to house dust mites, determination of endotoxin concentrations in house dust, evaluation of endotoxin on the severity of asthma.