论文部分内容阅读
目的进一步探讨骨原发性黄色瘤的性质、病理学特点及其鉴别诊断要点。方法观察5例骨原发性黄色瘤的临床病理特点,结合组化和免疫组化及随访资料进行综合分析。结果5例患者均为成人,肿瘤单发,分别位于枕骨、胫骨和股骨两端。X线示骨有膨胀性、溶骨性、破坏性病变。组织学以纤维组织细胞增生伴大量黄色瘤细胞聚集及多少不等的慢性炎症细胞为特点;组化及免疫组化显示黄色瘤细胞的组织细胞特点。结论骨原发性黄色瘤可能为一种骨的局灶性反应性脂质吸收性病变,主要应与含黄色瘤成分的其他良性骨病以及骨的转移性透明细胞癌鉴别。
Objective To further explore the nature of primary bone tumors, pathological features and the differential diagnosis. Methods The clinicopathological features of 5 cases of primary primary xanthoma were observed. The histopathological and immunohistochemical findings and follow-up data were used for comprehensive analysis. Results All the 5 patients were adults and had single tumors. They were located on the occipital, tibial and femur sides respectively. X-ray showed bone swelling, osteolytic, destructive lesions. Histology characterized by the proliferation of fibrous tissue with a large number of yellow tumor cells aggregated and the number of chronic inflammatory cells characterized by varying degrees; histochemistry and immunohistochemistry showed yellow tumor cells of the cell characteristics. Conclusion Bone primary xanthomas may be a kind of focal reactive lipid-absorbing lesions of bone, which should be distinguished from other benign bone diseases with xanthoma and metastatic clear cell carcinoma of bone.