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Background Previous studies found a range of prognostic factors but no consensus about the proper staging systemfor multiple myeloma has been achieved.This study explored the prognostic factors to find a staging system for multiplemyeloma most suitable for Chinese patients.Methods Between February 1990 to August 2004,206 patients(138 men and 68 women,mean aged (59±11) years)who were initially diagnosed as multiple myeloma in Changzheng Hospital (Shanghai,China) and had followup recordswere enrolled in this study.Potential prognostic factors were evaluated by univariate and multivariate analyses.Fourstaging systems were applied to compare their suitability for the patients.Results The median survival time of the patients was 33 months.The 1-,3-and 5-year survival rates were 80.18%,48.08% and 33.7% respectively.Factors identified as adversely affecting survival were older age,severe bone lesions,low haemoglobin,low platelet,low serum calcium,low serum albumin,high proportion of plasma cells in marrow,highserum creatinine,high serum β_2 microglobulin and high C-reactive protein.Among these,only C-reactive protein,β_2microglobulin,albumin and age were the independent prognostic factors.There were statistically significant survivaldifferences among the three groups in Durie Salmon staging system and Bataille staging system,but not in BritishMedical Research Council staging system or International Staging System.Conclusions High β_2 microglobulin,high C-reactive protein,low albumin and old age are independent prognosticfactors of multiple myeloma.Bataille staging system appears to be optimal for Chinese multiple myeloma patients.Chin Med J 2007;120(19):1655-1658
Background Previous studies found a range of prognostic factors but no consensus about the proper staging system for multiple myeloma has been. This study explored the prognostic factors to find a staging system for multiple myeloma most suitable for Chinese patients. Methods Between February 1990 and August 2004, 206 patients (138 men and 68 women, mean aged (59 ± 11) years) who were initially diagnosed as multiple myeloma in Changzheng Hospital (Shanghai, China) and had follow up recordswere enrolled in this study.Potential prognostic factors were evaluated by univariate and Results of The median survival time of the patients was 33 months. 1-, 3-and 5-year survival rates were 80.18%, 48.08% and 33.7% respectively. Factors identified as adversely affecting survival were older age, severe bone lesions, low hemoglobin, low platelet, low serum calcium, low serum albumin, high proportion of plasma c ells in marrow, highserum creatinine, high serum β_2 microglobulin and high C-reactive protein. Am I these only C-reactive protein, β_2microglobulin, albumin and age were the independent prognostic factors. Here are significant significant differences in the three groups in Durie Salmon staging system and Bataille staging system, but not in British Medical Research Council staging system or International Staging System. Conclusions High β_2 microglobulin, high C-reactive protein, low albumin and old age are independent prognostic factors of multiple myeloma. bataille staging system appears to be optimal for Chinese multiple myeloma patients. Chin Med J 2007; 120 (19): 1655-1658