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目的:探讨单独应用左旋多巴治疗帕金森病(PD)与多巴胺受体激动剂联合左旋多巴治疗的临床疗效对比。方法:采用随机抽选法从武汉科技大学附属武汉市汉阳医院2015年1月至2017年1月收治的PD患者中选取36例,单独使用左旋多巴治疗的16例患者为对照组,多巴胺受体激动剂联合左旋多巴治疗的20例患者为观察组,对两组患者疗效进行对比观察。结果:通过帕金森评定量表(UPDRS)对疗效的评分结果可以看出,两组患者在治疗前评分比较,差异无统计学意义(P>0.05),而治疗后两组均有明显降低,观察组患者降低的程度明显比对照组大,差异具有统计学意义(P<0.05)。结论:临床治疗PD联合应用多巴胺受体激动剂和左旋多巴具有更好的治疗效果,能有效改善患者临床症状,提高患者生活质量。
Objective: To investigate the clinical efficacy of levodopa alone in the treatment of Parkinson’s disease (PD) combined with dopamine agonist and levodopa. Methods: Thirty-six patients with PD were enrolled from Wuhan Hanyang Hospital Affiliated to Wuhan University of Science and Technology from January 2015 to January 2017. Sixteen patients treated with levodopa alone were the control group. The dopamine 20 patients treated with body agonist and levodopa were observed, and the curative effect of the two groups were compared. Results: According to the result of UPDRS score, there was no significant difference between two groups before treatment (P> 0.05), but after treatment, both groups were significantly lower, The degree of reduction in the observation group was significantly larger than that in the control group, with statistical significance (P <0.05). Conclusion: The clinical treatment of PD combined with dopamine agonist and levodopa has better therapeutic effect, which can effectively improve the clinical symptoms and improve the quality of life of patients.