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6个用反应停治疗的结节性痒疹或盘状红斑狼疮病人,4例出现手足感觉异常并1例主诉肌肉疼痛和痉挛。4例临床神经学检查全属正常。随后6个病人电生理学检查发现5例病人周围神经病变,其中2例多发性神经病变,3例腕管综合征。1例停止反应停一年后仍出现症状和电生理学异常。鉴于曾有报告证明反应停的神经毒性症状是长期
Of the 6 nontuberclized pruritus or lupus erythematosus patients treated with the response regimen, 4 had hand-foot sensory abnormalities and 1 complained of muscle aches and cramps. 4 cases of clinical neurological examination all normal. Followed by electrophysiological examination in 6 patients found that 5 patients with peripheral neuropathy, including 2 cases of multiple neuropathy, 3 cases of carpal tunnel syndrome. One patient stopped responding for one year after the onset of symptoms and electrophysiological abnormalities. In view of the long-term evidence that neurotoxicity has been reported to demonstrate response