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目的了解正常孕妇不同孕期和产科早期弥漫性血管内凝血(DIC)患者的凝血、抗凝血功能。方法检测31例早孕、31例中孕、32例晚孕、30例产科早期DIC和30例正常对照的常规止凝血功能实验室检测项目凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(Fbg)指标。结果 PT、APTT在各实验组间差异无统计学意义(P>0.05),Fbg随着妊娠时间的延长其浓度逐渐升高(P<0.05);早期DIC组Fbg(4.1±1.0)g/L与中孕组(3.9±0.8)g/L、晚孕组(4.2±0.5)g/L相比差异无统计学意义(P>0.05)。结论 Fbg可反映机体高凝状态,但不能早期诊断产科DIC。
Objective To investigate the coagulation and anticoagulation of normal pregnant women with diffuse intravascular coagulation (DIC) in different stages of pregnancy and obstetrics. Methods 31 cases of early pregnancy, 31 cases of second trimester, 32 cases of late pregnancy, 30 cases of obstetric early DIC and 30 cases of normal control coagulation function test items prothrombin time (PT), partial thromboplastin time (APTT ), Fibrinogen (Fbg) indicators. Results There was no significant difference in PT and APTT between the experimental groups (P> 0.05). The Fbg level gradually increased with the extension of gestation time (P <0.05). The Fbg (4.1 ± 1.0) g / L There was no significant difference between the third trimester group (3.9 ± 0.8) g / L and the second trimester group (4.2 ± 0.5) g / L (P> 0.05). Conclusion Fbg can reflect the state of hypercoagulability, but can not diagnose obstetric DIC early.