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目的:观察双重抗血小板药物治疗急性脑梗死的效果。方法:选择我院2010年2月—2012年2月神经内科收治的急性脑梗死患者100例,随机分为观察组与对照组,在行脑梗死基础治疗的同时对照组给予氯吡雷格75mg/日,观察组在对照组的治疗基础上加入阿司匹林肠溶片100mg/日,两组均以两周的治疗为一疗程。观察对比两组患入院时与用药两周后的血浆中血小板颗粒膜蛋白140、全血粘度、血浆粘度、血小板聚集率。结果:两组治疗两周后各项指标与同组治疗前对比,均具有明显差异,P<0.05,两组治疗两周后各项指标对比P<0.05,具有明显统计学意义。结论:急性脑梗死患者采用双重抗血小板药物治疗与单一运用抗血小板药物对比,明显提高了治疗效果,降低了死亡率,提高了预后效果与生活质量。
Objective: To observe the effect of dual antiplatelet drugs on acute cerebral infarction. Methods: A total of 100 acute cerebral infarction patients admitted to our department from February 2010 to February 2012 were randomly divided into observation group and control group. The patients in control group were given clopidogrel 75mg / Day, the observation group in the control group based on the treatment of aspirin enteric-coated tablets 100mg / day, two groups were treated with two weeks for a course of treatment. The plasma levels of platelet granule membrane protein 140, whole blood viscosity, plasma viscosity and platelet aggregation were observed in two groups after admission and two weeks after treatment. Results: After two weeks of treatment, the indexes in each group were significantly different from those in the same group before treatment (P <0.05). After two weeks of treatment, the indexes in each group were significantly lower than those in the control group (P <0.05), with significant statistical significance. Conclusion: Compared with the single antiplatelet drugs, the double antiplatelet drugs in patients with acute cerebral infarction significantly improve the treatment effect, reduce the mortality and improve the prognosis and quality of life.