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目的:探讨清开灵注射剂致过敏性休克的一般发生规律和特点,从而预防或避免其重复发生,为临床合理用药提供参考。方法:通过检索1994—2012年万方数据库和中国知网数据库中的医学期刊,收集清开灵注射剂致过敏性休克病例85例,对患者的一般情况、用药情况、过敏性休克发生情况等进行分析。结果:清开灵注射剂致过敏性休克85例病例中男40例(47.06%),女45例(52.94%),20~39岁年龄组患者发生率最高,占43.53%,其出现时间多发生于给药30 min内,均引起患者不同程度的器官损伤,并有10例死亡。结论:清开灵注射剂致过敏性休克的相关因素很多,且后果严重,临床医师、药师应了解其所致过敏性休克的规律和特点,加强其应用监测,以减少过敏性休克的发生。
Objective: To investigate the general rules and characteristics of anaphylactic shock caused by Qingkailing injection, so as to prevent or avoid recurrence and provide a reference for clinical rational drug use. Methods: A total of 85 cases of anaphylactic shock induced by Qingkailing injection were collected by searching medical journals in Wanfang database and CNKI database from 1994 to 2012. The general situation, medication status and occurrence of anaphylactic shock were collected analysis. Results: There were 40 males (47.06%) and 45 females (52.94%) in 85 cases of anaphylactic shock caused by Qingkailing injection, the highest incidence rate was 43.53% in 20 ~ 39 age group In the administration of 30 min, all patients were caused by varying degrees of organ damage, and 10 patients died. Conclusion: There are many factors related to anaphylactic shock caused by Qingkailing injection, and the consequences are serious. Clinicians and pharmacists should understand the regularity and characteristics of allergic shock and strengthen their monitoring to reduce the incidence of anaphylactic shock.