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目的 探讨血清特异性IgE(sIgE)在儿童支气管哮喘发病机制中的临床意义。方法 采用法玛西亚公司的免疫CAP诊断系统,以荧光酶联免疫法测定血清sIgE。结果 26 种吸入性及22 种食物性过敏原的sIgE中户尘螨、屋尘、蒿草、烟曲霉、鸡蛋白、牛奶、花生、黄豆8 种过敏原的阳性检出率较高。蒿草过敏原的阳性检出率为57.14%(20/35),年长儿检出率明显高于年幼儿,其秩和检验组间有明显差异(P< 0.05),户尘螨、屋尘等过敏原组间秩和检验无明显差异(P> 0.05)。结论 上述8 种过敏原是引起儿童外源性支气管哮喘的主要过敏原,随年龄增长血清吸入性过敏原的sIgE阳性率增加
Objective To investigate the clinical significance of serum specific IgE (sIgE) in the pathogenesis of bronchial asthma in children. Methods The immune CAP diagnostic system of Amagaso company was used to measure serum sIgE by fluorescence enzyme-linked immunosorbent assay. Results The positive detection rates of 8 allergens including 26 dust inhalers and 22 food allergens in sIgE were higher than those in house dust, house dust, wormwood, Aspergillus fumigatus, egg white, milk, peanut and soybean. The detection rate of the allergens in wormwood was 57.14% (20/35), the detection rate was significantly higher in older children than in young children (P <0.05) There was no significant difference in rank sum test between allergens such as dust (P> 0.05). Conclusions The above eight allergens are the major allergens causing extrinsic bronchial asthma in children. The sIgE positive rate of serum allergens increased with age