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用单克隆抗体酶联免疫吸附试验测定了15例流行性脑脊髓膜炎(流脑)患儿血清IgG亚类浓度,211名健康儿童作为对照。结果9例流脑患儿伴一种或多种IgG亚类缺陷,其中8例单一IgG_4缺陷或IgG_4伴其它亚类联合缺陷。提示IgG_4亚类缺陷,特别是IgG_4缺陷可能是重要的流脑易感因素。
Serum IgG subclass concentrations were measured in 15 children with epidemic cerebrospinal meningitis (MC) using the monoclonal antibody enzyme-linked immunosorbent assay, and 211 healthy children served as controls. Results Nine children with meningitis had one or more IgG subclass deficiencies, of which eight had single IgG4 defects or IgG4 allograft defects. Suggesting that IgG4 subclass defects, particularly IgG4 defects, may be important meningococcal susceptibility factors.