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目的 :探讨用盐酸美金刚治疗老年帕金森病所致痴呆的临床效果。方法 :对2012年1月~2015年1月期间在我院进行治疗的60例老年帕金森病所致痴呆患者的临床资料进行回顾性研究。我们将这60例患者随机分为观察组和对照组,每组各有30例患者。我院为观察组患者使用盐酸美金刚进行治疗,为对照组患者使用盐酸多奈哌齐进行治疗。在进行治疗的过程中,比较两组患者的Mo-CA量表评分和MMSSE量表评分。治疗结束后,比较两组患者对临床治疗的满意率及不良反应的发生情况。结果:在进行就诊时,两组患者的Mo-CA量表评分和MMSSE量表评分相比差异均不具有显著性(P>0.05)。在进行治疗的第4周、第10周及第16周,观察组患者的Mo-CA量表评分和MMSSE量表评分均显著优于对照组患者,二者相比差异具有显著性(P<0.05)。观察组患者对临床治疗的满意率明显好于对照组患者,二者相比差异具有显著性(P<0.05)。在进行治疗期间,两组患者不良反应的发生率相比差异不具有显著性(P>0.05)。结论 :用盐酸美金刚治疗老年帕金森病所致痴呆的效果显著。此治疗方法值得在临床上推广应用。
Objective: To investigate the clinical efficacy of memantine hydrochloride in treating dementia caused by senile Parkinson’s disease. Methods: The clinical data of 60 elderly patients with dementia caused by senile Parkinson’s disease treated in our hospital from January 2012 to January 2015 were analyzed retrospectively. We randomly divided the 60 patients into observation and control groups, each with 30 patients in each group. In our hospital, the patients in the observation group were treated with memantine hydrochloride, and the patients in the control group were treated with donepezil hydrochloride. During the course of treatment, the Mo-CA scale and the MMSSE scale were compared between the two groups. After the treatment, the satisfaction rate of the two groups of patients on clinical treatment and adverse reactions were compared. Results: There was no significant difference in MoCA scale score and MMSSE scale score between the two groups (P> 0.05). At the 4th week, the 10th week and the 16th week of treatment, the scores of Mo-CA and MMSSE in observation group were significantly better than those in control group, the difference was significant (P < 0.05). The satisfaction rate of clinical observation group was significantly better than that of the control group, the difference was significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P> 0.05). Conclusion: The effect of memantine hydrochloride on dementia caused by senile Parkinson’s disease is remarkable. This treatment is worth promoting in clinical application.