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有证据显示正常胃肠道粘膜组织、血管周围均有纤溶酶原激活物,而人的门静脉内经常有内毒素存在;前者可激活纤溶活动,后者可引起血管内异常凝血。肝脏的网状内皮系统能清除这些物质,调节纤溶活动,在止血中起重要作用。为此,作者测定门静脉与外周静脉血中纤溶与纤凝物质,以研究胃肠道对纤溶活性的调节。病人和方法:第一组,无并发症之胆石症12例。行剖腹术时,在门静脉与肘静脉处穿刺抽取抗凝血,离心、低温保存;分别测定优球蛋白溶解时间(ELT)、纤维蛋白原、纤溶酶原量、连续稀释鱼精蛋白试验(SDPS)、乙醇胶试验等。第二组肿瘤病人8例(胰腺癌5例,胃癌3例)其中有肝转移3例。同法抽取凝固血,同时行葡萄球菌集落试验(SCT)。结果行统计学处理。
There is evidence that normal gastrointestinal mucosal tissue, perivascular have plasminogen activator, while the human portal vein often have endotoxin exist; the former can activate fibrinolytic activity, which can cause abnormal blood coagulation. The reticuloendothelial system of the liver can remove these substances, regulate fibrinolytic activity and play an important role in hemostasis. To do this, the authors measured fibrinolysis and fibrinolysis in portal and peripheral venous blood to study the regulation of fibrinolytic activity in the gastrointestinal tract. Patients and Methods: The first group of 12 cases of cholelithiasis without complications. During laparotomy, anticoagulants were obtained by puncturing the portal vein and elbow vein, centrifuging and cryopreservation. The concentrations of euglobulin lysis (ELT), fibrinogen, plasminogen and continuous dilution of protamine ( SDPS), alcohol glue test. The second group of tumor patients in 8 cases (5 cases of pancreatic cancer, 3 cases of gastric cancer) in which liver metastases in 3 cases. Coagulation with the same method of extraction of blood, staphylococcus simultaneously colony assay (SCT). The results were statistically processed.