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听源性癫痫是由强烈声音刺激引起的癫痫,因其发作时伴全身性肌痉挛,所以又称为听源性痉挛(Audiogenic Seizure,AS),鼠、兔和人都可能发生.鼠AS于1922年在巴甫洛夫实验室首先发现,现已成为研究人类癫痫较好的实验模型,因而受到普遍重视.动物AS模型同电休克或药物性痉挛模型比有以下优点:1.方法简便,不因电或化学处理而造成损伤;2.AS在先天性、反射性及药物试验等方面都酷似人类癫痫,说明其生理学基础接近人类癫痫,研究AS可以获得用电或药物性痉挛模型难以获得的重要知识;3.AS发作后,除小鼠强直
Acoustic epilepsy is a type of epilepsy caused by a strong acoustic stimulus, which occurs in mice, rabbits and humans due to its onset of generalized muscle spasms, also known as Audiogenic Seizure (AS) First discovered in Pavlov’s laboratory in 1922, it has become a good experimental model for studying human epilepsy and therefore has received widespread attention. The animal model has the following advantages over the model of electroshock or drug-induced spasticity: 1. The method is simple, Not due to electrical or chemical treatment caused damage; 2.AS in the congenital, reflex and drug testing resembles human epilepsy, indicating its physiological basis close to human epilepsy, the study of AS can get electricity or drug spasm model is difficult to obtain Of the important knowledge; 3.AS attack, in addition to mouse ankylosis