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目的:检测子宫内膜异位症(EM)患者在位和异位子宫内膜中HLA-DR(人类白细胞抗原DR分子)及ICAM-1(细胞粘附分子-1)的表达,探讨它们在EM免疫发病机制中的意义。方法:采用免疫组织化学(SP)法分别测定EM患者在位和异位内膜及正常对照组子宫内膜中HLA-DR和ICAM-1的表达。结果:HLA-DR和ICAM-1在EM患者的异位内膜表达较在位内膜及正常对照组子宫内膜强,差异有统计学意义(P<0.05);HLA-DR和ICAM-1在在位内膜和正常对照组子宫内膜中的表达比较,差异无统计学意义(P>0.05);HLA-DR和ICAM-1在在位子宫内膜的表达呈周期性变化,增生期表达高于分泌期,二者比较差异有统计学意义(P<0.05);正常组子宫内膜的表达在增生期高于分泌期,但差异无统计学意义(P>0.05);HLA-DR和ICAM-1在异位内膜和在位内膜的表达均呈正相关,即同向表达。结论:HLA-DR、ICAM-1在EM患者异位内膜中的表达升高。这些异常变化导致EM患者腹腔局部免疫微环境发生变化,促进了EM的发生发展。
Objective: To detect the expression of HLA-DR (human leukocyte antigen DR) and ICAM-1 (cell adhesion molecule-1) in eutopic and ectopic endometrium of patients with endometriosis (EM) Significance of EM Pathogenesis. Methods: The expressions of HLA-DR and ICAM-1 in eutopic and ectopic endometrium of ectopic and eutopic endometrium of EM patients were determined by immunohistochemistry (SP). Results: The expression of HLA-DR and ICAM-1 in ectopic endometrium of patients with EM was stronger than that of eutopic endometrium and normal control group (P <0.05). The expression of HLA-DR and ICAM-1 The expression of HLA-DR and ICAM-1 in the eutopic endometrium showed a periodic change in the endometrium and the normal control group (P> 0.05), while the proliferative phase (P <0.05). The expression of endometrium in normal group was higher than that in secretory phase, but the difference was not statistically significant (P> 0.05). The expression of HLA-DR And ICAM-1 expression in ectopic and eutopic endometrium were positively correlated, that is, the same direction. Conclusion: The expression of HLA-DR and ICAM-1 in ectopic endometrium of EM patients is increased. These abnormal changes lead to changes in the peritoneal immune immune microenvironment in EM patients and promote the development of EM.