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妊娠相关子宫内膜蛋白glycodelin是一组糖蛋白,属于脂质载体蛋白lipocalin超家族。目前发现有4种亚型,分别具有不同的生理作用。glycodelin在人体内多种组织中有表达,其表达水平受到多种因素的调控,主要在免疫抑制、诱导细胞分化、促血管生成以及调节精子与透明带的结合等方面发挥作用。随着研究的深入,发现其在妊娠过程中发挥重要作用,并与部分妊娠相关疾病如流产、异位妊娠、子痫前期、妊娠期糖代谢异常等关系密切。就近年glycodelin的相关研究作一综述。
Pregnancy-associated endometrial glycodelin is a group of glycoproteins that belong to the lipocalin superfamily of lipid carriers. Currently there are 4 subtypes, which have different physiological roles. Glycodelin is expressed in many tissues of the human body. The expression of glycodelin is regulated by many factors, such as immunosuppression, induction of cell differentiation, proangiogenesis, and regulation of sperm-zona pellucida binding. With the deepening of research, we found that it plays an important role in the process of pregnancy, and is closely related to some pregnancy-related diseases such as miscarriage, ectopic pregnancy, preeclampsia, abnormal glucose metabolism during pregnancy. In recent years, glycodelin related research for a review.