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目的:总结手术切除加局部注射平阳霉素治疗小儿血管瘤和血管畸形的临床效果。方法:本组56例小儿血管瘤,行手术切除大部分瘤体、残余瘤体内注射平阳霉素治疗。术中将配好的平阳霉素分点注射进肿瘤组织内,注射时根据患者的年龄,血管瘤的范围决定注射剂量,一般每一点注射2ml-4ml,以瘤体轻度发白为度,一次注射总量不超过24mg。第一次注射后一期缝合创面,之后每两周注射一次。结果:32例经手术及3次注射治愈(57.14%);13例经3次注射治愈(23.21%);9例经5次注射治愈(16.07%);2例无效(3.57%),治愈率为96.4%。56例中切口感染2例,经抗感染及交换敷料治愈;注射后引起患儿发热2例,体温37.6℃-38.2℃,经对症处理缓解。未见发生药物过敏或中毒现象。患儿生长发育正常。结论:平阳霉素注射可以配合手术用于不能全部切除的小儿血管瘤和血管畸形的治疗。
Objective: To summarize the clinical effects of surgical resection plus local injection of pingyangmycin in the treatment of pediatric hemangiomas and vascular malformations. Methods: The group of 56 cases of pediatric hemangiomas, the majority of surgical resection of the tumor, the remaining tumor in vivo injection of pingyangmycin treatment. Intraoperative will be equipped with good Pingyangmycin injected into the tumor tissue points, according to the injection of the patient’s age, hemangiomas determine the injection dose range, usually every injection of 2ml-4ml, with a mild degree of tumor whitening, A total injection does not exceed 24mg. The first injection after a period of suture wounds, then injected once every two weeks. Results: 32 cases were cured by operation and 3 injections (57.14%), 13 cases were cured by 3 injections (23.21%), 9 cases were cured by 5 injections (16.07%), 2 cases were ineffective (3.57%), the cure rate 96.4%. In 56 cases incision infection in 2 cases, anti-infective and exchange dressing cure; injection caused 2 cases of fever in children, body temperature 37.6 ℃ -38.2 ℃, relieved symptomatically. No drug allergy or poisoning occurred. Children grow and develop normally. Conclusion: Pingyangmycin injection can be used in conjunction with surgery for the treatment of pediatric hemangiomas and vascular malformations that can not be completely resected.