A preliminary comparison of motor learning across different non-invasive brain stimulation paradigms

• 出 处: 中华物理医学与康复杂志
• 发表日期: 2019年41期

BACKGROUND AND OBJECTIVE

Non-invasive brain stimulation (NIBS) has been widely explored as a way to safely modulate brain activity and alter human performance for nearly three decades. Research using NIBS has grown exponentially within the last decade with promising results across a variety of clinical and healthy populations. However, recent work has shown high inter-individual variability and a lack of reproducibility of previous results. Here, we conducted a small preliminary study to explore the effects of three of the most commonly used excitatory NIBS paradigms over the primary motor cortex (M1) on motor learning (Sequential Visuomotor Isometric Pinch Force Tracking Task) and secondarily relate changes in motor learning to changes in cortical excitability (MEP amplitude and SICI)．

METHODS

We compared anodal transcranial direct current stimulation (tDCS), paired associative stimulation (PAS25), and intermittent theta burst stimulation (iTBS), along with a sham tDCS control condition. Stimulation was applied prior to motor learning. Participants (n＝28) were randomized into one of the four groups and were trained on a skilled motor task. Motor learning was measured immediately after training (online), 1 day after training (consolidation), and 1 week after training (retention)．

RESULTS

We did not find consistent differential effects on motor learning or cortical excitability across groups.

CONCLUSION

Within the boundaries of our small sample sizes, we then assessed effect sizes across the NIBS groups that could help power future studies.These results, which require replication with larger samples, are consistent with previous reports of small and variable effect sizes of these interventions on motor learning.