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目的:研究复方槲皮素乳膏的最佳基质处方组成。方法:以油相、乳化剂、二甲亚砜(DMSO)、盐酸的用量为考察因素,以外观性状、粒度、均匀性、稳定性、酸碱性的综合评分为指标,采用均匀设计试验筛选处方并验证。结果:复方槲皮素乳膏的最佳基质处方组成为:每100 g成品含白凡士林21.2 g、十八醇6.5 g、单硬脂酸甘油酯6.9 g、十二烷基硫酸钠1.2 g、DMSO 2.4 g。结论:按此处方制备的复方槲皮素乳膏具有外观细腻均匀、易涂抹、稳定性好的特点,符合《中华人民共和国药典》2010年版乳膏项下有关规定。
Objective: To study the optimal formulation of compound quercetin cream. Methods: Taking the amount of oil phase, emulsifier, dimethylsulfoxide (DMSO) and hydrochloric acid as the investigation factors and taking the comprehensive evaluation of appearance, grain size, uniformity, stability and acidity and alkalinity as indexes, Prescription and validation. Results: The prescription of compound quercetin cream was as follows: per 100 g of finished product, 21.2 g of white petrolatum, 6.5 g of octadecanol, 6.9 g of glyceryl monostearate, 1.2 g of sodium lauryl sulfate, DMSO 2.4 g. CONCLUSION: The compound quercetin cream prepared by this prescription has the characteristics of delicate and uniform appearance, easy application and good stability, which is in conformity with the relevant provisions under the 2010 edition of the Chinese Pharmacopoeia, People’s Republic of China.