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目的:观察益气养阴方对非小细胞肺癌(NSCLC)围手术期患者免疫功能的影响。方法:纳入46例行肺叶切除术的气阴两虚证NSCLC患者,随机分为对照组和治疗组,每组各23例。对照组按术后常规治疗,治疗组在对照组治疗的基础上,于术后第1天加用中药益气养阴方治疗,观察周期为4期。分别于术后第1天及术后4周检测所有患者的CD3~+、CD4~+、CD8~+、CD4~+/CD8~+水平。结果:治疗后,治疗组患者的CD3~+、CD4~+、CD4~+/CD8~+水平较治疗前均显著升高(P<0.05),CD8~+水平显著降低(P<0.05);对照组患者仅CD4~+/CD8~+水平较治疗前显著升高(P<0.05);且治疗组患者的CD3~+、CD4~+、CD4~+/CD8~+水平明显高于对照组(P<0.05)。结论:在NSCLC患者围手术期应用益气养阴方可减轻患者的免疫抑制程度,促进患者免疫功能的恢复。
Objective: To observe the effects of Yiqi Yangyin Recipe on the immune function of perioperative patients with non-small cell lung cancer (NSCLC). Methods: Forty-six NSCLC patients with pneumothorax and pneumonia were randomly divided into control group and treatment group, with 23 cases in each group. The control group according to conventional postoperative treatment, the treatment group in the control group based on the treatment, on the first day after surgery with traditional Chinese medicine Yiqi Yangyin Fang treatment, the observation period of 4. The levels of CD3 ~ +, CD4 ~ +, CD8 ~ +, CD4 ~ + / CD8 ~ + in all patients were detected on the first postoperative day and the fourth postoperative day respectively. Results: After treatment, the levels of CD3 +, CD4 +, CD4 + / CD8 + in treatment group were significantly higher than those before treatment (P <0.05) and CD8 + was significantly decreased (P <0.05). The level of CD4 ~ + / CD8 ~ + in the control group was significantly higher than that before treatment (P <0.05). The levels of CD3 +, CD4 +, CD4 + / CD8 + in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion: The application of Yiqi Yangyin in perioperative period can reduce the degree of immunosuppression in patients with NSCLC and promote the recovery of immune function.