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磷酸化AKt(pAKt)是近年来发现与胚胎着床密切相关的分子标志之一。目前的研究认为其主要通过促进子宫内膜蜕膜化、诱导卵泡发育与成熟、促进植入前胚胎发育、增加胚胎种植潜能而促进胚胎着床。pAKt在胚胎着床中的作用主要通过环磷腺苷(cAMP)/AKt、磷脂酰肌醇3-激酶(PI3-K)/Akt信号转导途,一系列的激素如雌孕激素、胰岛素等和细胞因子如胰岛素样生长因子-I(IGF-I)、转化生长因子-β1(TGF-β1)、表皮生长因子(EGF)等影响pAKt的作用。
Phosphorylated AKt (pAKt) is one of the molecular markers closely related to embryo implantation in recent years. The current study suggests that it promotes embryo implantation mainly by promoting endometrial decidualization, inducing follicular development and maturation, promoting preimplantation embryo development and increasing embryo implantation potential. The role of pAKt in embryo implantation is mainly mediated by cyclic adenosine monophosphate (cAMP) / AKt, phosphatidylinositol 3-kinase (PI3-K) / Akt signaling, a series of hormones such as estrogen, progesterone and insulin And cytokines such as insulin-like growth factor-I (IGF-I), transforming growth factor-β1 (TGF-β1), epidermal growth factor (EGF) affect pAKt.