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目的探讨儿童急性白血病患者血清中胰岛素样生长因子1(IGF-1)和白血病抑制因子(LIF)的水平及其临床意义。方法利用酶联免疫吸附法对86例急性白血病患儿进行化疗后血清IGF-1及LIF水平,并与45例正常健康儿童进行比较。结果不同治疗阶段急性白血病患儿血清中IGF-1和LIF水平存在差别,初诊未治组IGF-1水平最低,随治疗时间增长,IGF-1及LIF水平逐渐上升,初诊未治组与短期CR组、长期CR组间差异有统计学意义(P<0.05);正常对照组IGF-1和LIF水平与短期CR组、长期CR组比较,差异无统计学意义(P>0.05)。结论 IGF-1和LIF水平可作为评判儿童急性白血病病情发展和治疗效果的重要指标。
Objective To investigate the serum level of insulin-like growth factor 1 (IGF-1) and leukemia inhibitory factor (LIF) in children with acute leukemia and its clinical significance. Methods Serum IGF-1 and LIF levels were measured in 86 children with acute leukemia by enzyme-linked immunosorbent assay and compared with 45 healthy children. Results The levels of IGF-1 and LIF in serum of children with acute leukemia at different treatment stages were different. The IGF-1 level in the untreated group was the lowest. With the increase of treatment time, the levels of IGF-1 and LIF gradually increased. (P <0.05). The levels of IGF-1 and LIF in normal control group were not significantly different from those in short-term CR group and long-term CR group (P> 0.05). Conclusion IGF-1 and LIF levels may be used as an important index to judge the development of children’s acute leukemia and the therapeutic effect.