Prospects for nucleic acid-based therapeutics against hepatitis C virus

• 作 者: Chang Ho Lee Ji Hyun Kim Seong
• 机 构: DepartmentofMolecularBiology
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2013年47期
• 关键词: Hepatitis C virus Nucleic acid-based THERAPEUTICS RIBOZYME APTAMER siRNA ANTISEN
• 基金项目: Supported by National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning No.2012M3A9B6055200,No.2013R1A2A2A01004649

In this review,we discuss recent advances in nucleic acid-based therapeutic technologies that target hepatitis C virus(HCV)infection.Because the HCV genome is present exclusively in RNA form during replication,various nucleic acid-based therapeutic approa