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已有研究表明,一些药物能够减少口服避孕药的功效,并提出了一些不同的机制。广谱抗菌素与导致避孕药失败的原因有关。根据动物实验表明,抗生素能通过阻碍炔雌醇的肠肝循环,从而减少口服避孕药的活性。在应用口服避孕药期间的妇女,为确定其并用氨苄青霉素的疗效已进行了研究。 13名妇女长期应用类甾醇类避孕药,当服用氨苄青霉素(500mg,3/日,共8
Studies have shown that some drugs can reduce the efficacy of oral contraceptives and put forward some different mechanisms. Broad-spectrum antibiotics lead to the failure of contraceptives. According to animal experiments show that antibiotics can inhibit the ethinyl estradiol enterohepatic circulation, thereby reducing the activity of oral contraceptives. In the application of oral contraceptives in women, to determine its efficacy with ampicillin has been studied. Thirteen women used long-term steroid-based contraceptives when taking ampicillin (500 mg, 3 / day, a total of 8