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目的:观察溶岩胶囊维持治疗晚期非小细胞肺癌(NSCLC)对患者生存期的影响。方法:根据纳入标准选入74例晚期NSCLC患者,随机分为治疗组38例与对照组36例。治疗组给予溶岩胶囊维持治疗,对照组随访观察,统计两组维持治疗中位生存期(MST)及疾病无进展生存期(PFS)。组间临床特征采用方差分析,MST与PFS比较采用Kplan-Meier分析。结果:入组70例,4例出组,70例可评价疗效,治疗前两组基线资料分布均衡(P>0.05)。治疗组和对照组MST分别为6.23月、2.7月(P=0.00)。治疗组和对照组PFS分别为4.8月、2.37月(P=0.00)。结论:中药溶岩胶囊维持治疗可延长中晚期NSCLC患者中位生存期及无进展生存期。
Objective: To observe the effect of Vital Capsule in the treatment of advanced non-small cell lung cancer (NSCLC) on the survival of patients. Methods: According to the inclusion criteria, 74 patients with advanced NSCLC were selected and randomly divided into treatment group (38 cases) and control group (36 cases). The treatment group was given LYR capsule maintenance treatment, and the control group was followed up. The median survival time (MST) and disease-free survival (PFS) were calculated. The clinical characteristics of the groups using analysis of variance, MST and PFS compared using Kplan-Meier analysis. Results: 70 cases were enrolled, 4 cases were given out and 70 cases could be evaluated. The baseline data of the two groups before treatment were balanced (P> 0.05). The MST of the treatment group and the control group were 6.23 months and 2.7 months (P = 0.00). The PFS of the treatment group and the control group were 4.8 months and 2.3 months (P = 0.00), respectively. Conclusion: The traditional Chinese medicine Lagen capsule can prolong the median survival and progression-free survival of patients with advanced NSCLC.