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目的:观察中西医结合治疗老年人原发性肾病综合征(INS)的临床疗效。方法:82例老年人INS患者随机分为治疗组和对照组。治疗组(41例)用强的松和环磷酰胺(CTX)并辨证加服中药,对照组(41例)单纯用西药治疗。观察临床缓解率、副反应率、复发率及缓解时间。结果:治疗组完全缓解率(585%)和总缓解率(854%)均显著高于对照组(390%、634%,P<001)。治疗组副反应率(366%)明显低于对照组(805%,P<001)。随访(351±97)个月后,治疗组复发率(83%)与对照组(250%)比较无显著性差异(P>005)。但治疗组平均缓解期为(306±38)个月,较对照组〔(127±37)个月〕显著延长(P<001)。结论:中西医结合治疗老年人原发性肾病综合征优于单纯西医治疗。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in treating elderly patients with primary nephrotic syndrome (INS). Methods: 82 elderly INS patients were randomly divided into treatment group and control group. The treatment group (41 cases) was treated with prednisone and cyclophosphamide (CTX) and Chinese herbs. The control group (41 cases) was treated with western medicine alone. Clinical remission rate, side effects, recurrence rate and remission time were observed. Results: The complete remission rate (585%) and total remission rate (854%) in the treatment group were significantly higher than those in the control group (390%, 634%, P <001). The response rate of the treatment group (366%) was significantly lower than that of the control group (805%, P <001). After a follow-up of (351 ± 97) months, there was no significant difference between the treatment group (83%) and the control group (250%) (P> 005). However, the mean remission rate in the treatment group was (306 ± 38) months, significantly longer than that in the control group (127 ± 37 months) (P <001). Conclusion: The combination of TCM and Western medicine treatment of elderly patients with primary nephrotic syndrome is better than Western medicine alone.