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母儿传播HIV-1可发生于宫内期、分娩时及产后。胎盘垂直传播可能为其主要途径,但确切机制尚不清楚。为探求CD4+细胞与p~(24)抗原血症(HIV-1)在母儿间传播中的作用,作者对29例早孕期HIV-1阳性孕妇之母儿进行前瞻性研究。 1985年11月～1991年6月对29例早孕期(最长孕周13周)发现HIV-1阳性的孕妇,三个月复查一次淋巴细胞亚群,22例行p~(24)抗原检测。所分娩新生儿随诊18个月。母亲分娩时年龄、受教育程度、孕产次、孕周、分娩方式等一般情况无差异。母儿感
Mother-child transmission of HIV-1 can occur in the uterus, childbirth and postpartum. Vertical transmission of the placenta may be the main way, but the exact mechanism is not clear. In order to explore the role of CD4 + cells in preventing mother-to-child transmission of HIV-1, 24 pregnant women with HIV-1 in their first trimester were prospectively studied. From November 1985 to June 1991, 29 pregnant women with HIV-1 positive pregnancy were found in the first trimester (the longest gestational age was 13 weeks), lymphocyte subsets were examined in three months, and 22 cases were detected with p ~ (24) antigen . The birth of newborns were followed up for 18 months. The mother’s childbearing age, education, motherhood, gestational age, mode of delivery and other general situation no difference. Maternal and child feeling