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目的检测子痫前期血清降钙素原(PCT)和C-反应蛋白(CRP)水平,为子痫前期的临床诊断、严重程度及预后评估提供依据。方法选择2015年1月-2015年10月吉林省妇幼保健院子瘤前期患者80例(研究组),轻度、重度各40例,随机选取同期正常妊娠晚期孕妇50例(正常对照组)。结果研究组患者血清PCT、CRP及阳性率分别为(2.38±0.57)μg/L、(22.96±1.13)mg/L和88.75%、83.75%,均高于正常对照组,差异有统计学意义(P<0.05);严重患者血清PCT、CRP及阳性率分别为(3.45±1.17)μg/L、(24.24±1.20)mg/L和95.00%、90.00%,均高于轻度患者,差异有统计学意义(P<0.05),研究组治疗后患者血清PCT、CRP及阳性率分别为(0.52±0.36)μg/L、(8.05±0.79)mg/L和10.00%、6.25%,均低于治疗前,治疗前后比较,差异有统计学意义(P<0.05)。结论子痫前期患者血清PCT、CRP显著升高,且随着严重程度而上升,治疗后血清PCT、CRP均下降,有助于子痫前期患者的早期诊断和预后评估。
Objective To detect the levels of serum procalcitonin (PCT) and C-reactive protein (CRP) in preeclampsia and to provide evidence for the clinical diagnosis, severity and prognosis of preeclampsia. Methods 80 patients (study group) from March 2015 to October 2015 in Jilin Province Maternal and Child Health Hospital were enrolled in this study. Forty mild and severe cases were selected. Fifty pregnant women of the same period of normal pregnancy were selected randomly as the control group. Results The serum PCT, CRP and the positive rate in the study group were (2.38 ± 0.57) μg / L, (22.96 ± 1.13) mg / L and 88.75%, 83.75%, respectively, which were significantly higher than those in the normal control group (3.45 ± 1.17) μg / L, (24.24 ± 1.20) mg / L and 95.00%, 90.00%, respectively, which were higher than those in mild patients (0.52 ± 0.36) μg / L, (8.05 ± 0.79) mg / L and 10.00%, 6.25%, respectively, were lower than those of the treatment group (P <0.05) Before and after treatment, the difference was statistically significant (P <0.05). Conclusions Serum PCT and CRP levels in patients with preeclampsia were significantly increased and increased with severity. After treatment, serum PCT and CRP levels were decreased, which was helpful for the early diagnosis and prognosis evaluation of patients with preeclampsia.