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乳腺是由大汗腺衍化而成的激素依赖型皮肤附属物,也是哺乳动物重要的生殖器官。脊椎动物大部分器官的基本结构至成年时保持相对恒定,但乳腺的结构一直不断改变[1-3]。青春期后受下丘脑-垂体-性腺的调控,乳腺形态呈周期性循环变化,最终经过妊娠发育成熟泌乳,所以哺乳是雌性生殖生理的延续。毒物所致的乳汁数量或质量下降会导致幼崽产生发育毒性。近年乳腺疾病发病率的增高已证实与内分泌干扰物密切相关[4],如何评价这些干扰物对人类健康的影
The mammary gland is a hormone-dependent skin appendage derived from apocrine glands and is also an important reproductive organ in mammals. The basic structure of most organs of vertebrates remains relatively constant to adulthood, but the structure of the breast has been constantly changing [1-3]. After puberty by the hypothalamus - pituitary - gonadal regulation, the cycle of cyclical changes in the shape of the breast, and eventually through the mature mature lactation, so lactation is a reproductive female reproductive physiology. Poison-induced decline in the quantity or quality of milk can cause developmental toxicity in pups. In recent years, the increased incidence of breast disease has been confirmed and endocrine disruptors are closely related [4], how to evaluate the impact of these interferents on human health