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恶性肿瘤的发生与染色体不稳定性之间的关系是当今肿瘤基础研究的重要课题之一。许多学者对不同恶性肿瘤的研究表明:肿瘤患者外周血染色体结构畸变在某种程度上可反映肿瘤细胞在生物学特性、肿瘤病程演变和发展。近年来研究表明:核仁组成区(NORs)是细胞周期一定时期细胞核中出现的环型卷曲的DNA,主要由核糖体RNA
The relationship between the occurrence of malignant tumors and chromosomal instability is one of the important topics in the basic research of cancer today. Many scholars of different malignant tumors showed that: chromosome aberrations in the peripheral blood of tumor patients to some extent may reflect the biological characteristics of tumor cells, tumor progression and development. In recent years, studies have shown that nucleolar organizer regions (NORs) are circular curly DNA appearing in the cell nucleus at a certain stage of the cell cycle and are mainly composed of ribosomal RNA