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已证明用人砂眼衣原体给小鼠鼻腔接种,可引起小鼠的间质性肺炎,其临床表现轻微,有自限性。炎症多在感染后第二天达高峰,7～14天消退。为了解衣原体的隐伏、慢性及复发感染的本质,作者用考的松处理小鼠,作了进一步探讨。以每毫升含10~8包涵体形成单位(IFU)的砂眼衣原体的HeLa细胞0.04毫升接种予小鼠鼻腔。14天后,给予醋酸考的松皮下注射(剂量为125mg/kg),隔日一次,共12天。在感染后2天、14天及考的松处理后隔日一次,分批处死小鼠,进行肺组织衣原体分离、肺组织学检查、血清抗体测定及毛细管移动抑制试验,观察考的松对机体的影
Has proved that the use of trachoma trachomatis to mice nasal vaccination, can cause interstitial pneumonia in mice, its clinical manifestations of minor, self-limiting. Inflammation reached the peak the next day after infection, 7 to 14 days subsided. In order to understand the nature of chlamydia’s latent, chronic and recurrent infections, the authors further investigated the treatment of mice with testosterone. 0.04 ml of HeLa cells of Chlamydia trachomatis containing 10 to 8 inclusion body forming units (IFU) per ml was inoculated into the mouse nasal cavity. After 14 days, given subcutaneous injection of acetic acid test (dose 125mg / kg) every other day, a total of 12 days. Mice were sacrificed in batches after 2 days, 14 days and 6 weeks after the test of cortisone, respectively. Chlamydia isolation, lung histology examination, serum antibody test and capillary migration inhibition test were performed on the lungs. shadow