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给大鼠腹腔注射ＭｎＣｌ＿２·４Ｈ＿２Ｏ１５ｍｇ·ｋｇ￣（－１）·ｄ￣（－１），分期分别为４、８、１６周，然后给予ＰＡＳ－Ｎａ１２０ｍｇ·ｋｇ￣（－１）·ｄ￣（－１）３周，用光镜和电镜观察其对睾丸组织病理改变的影响。结果发现，染锰３周后，大鼠睾丸部分曲细精管表现管腔变窄，精细胞呈不规则状，各级精细胞减少，管腔内精子少或无。支持细胞底部溶酶体增多。随着染锰时间延长（１６周），睾丸的损害愈益严重，睾丸脏器系数明显小于对照组（Ｐ＜０．０５）。经ＰＡＳ－Ｎａ治疗后，精细胞中出现溶酶体，但无变性坏死的表现。在光镜下除见极少萎缩的曲细精管外，其余基本恢复正常，提示ＰＡＳ－Ｎａ可拮抗锰对睾丸的损害。
Rats were injected intraperitoneally with MnCl 2 · 4H 2 O 15 mg · kg -1 · d -1 and were staged for 4, 8 and 16 weeks, respectively, and then administered with PAS-Na 120 mg · kg -1 · d -1 1) for 3 weeks. The pathological changes of testis were observed with light microscope and electron microscope. The results showed that after 3 weeks of manganese exposure, the testicular seminiferous tubules showed narrowing of the seminiferous tubules, abnormal sperm cells, reduced spermatids at all levels, and less or no intracavitary spermatozoa. Supports increased basal cell lysosomes. With the extension of manganese time (16 weeks), the damage of testis became more and more serious. The testis organ coefficient was significantly lower than that of control group (P <0.05). After PAS-Na treatment, spermatids appeared in spermatids but showed no signs of degeneration and necrosis. In addition to light microscopy see very little shrinking seminiferous tubules, the rest returned to normal, suggesting that PAS-Na can antagonize manganese damage to the testes.