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The median follow-up of the malignant glioma patients who received surgical resection combined with radiochemotherapy is 16 months.The recurrence of malignant glioma is unavoidable.Although the patient with recurrent glioblastoma has multiple choices of therapy,the 5-year survival rate is still less than 5%,and the average survival time is less than 12 months.[1] Currently,there is no single second-line drug can have survival benefits.