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由于放疗、手术和化疗的联合使用,很多儿童期恶性肿瘤预后获得改善,但这些治疗除对正常组织急性损害外,亦产生一些晚期影响,特别是在生殖和卵巢产生固醇类激素上,结果导致闭经、第二性征减退或消失,不孕和严重影响儿童精神发育.有关儿童期恶性肿瘤治疗后卵巢功能的材料甚少.本文综述了儿童期恶性肿瘤治疗后对女性生殖和性腺功能的影响,至于孕期治疗后致畸问题未包括在内,但对孕前治疗对后代的影响作了评述.
Due to the combined use of radiotherapy, surgery and chemotherapy, many childhood malignancies have improved prognosis, but these treatments have some late effects in addition to acute damage to normal tissues, particularly in reproductive and ovarian steroid hormones, with the result that Leading to amenorrhea, secondary sexual diminished or disappeared, infertility and seriously affect the mental development of children.On the basis of childhood ovarian function after treatment of malignant tumors is very small.This article reviews the treatment of female reproductive and sexual gland function Affect, as teratogenic treatment after pregnancy is not included, but the effects of pre-pregnancy treatment on future generations were reviewed.