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按正交及配对实验设计，将水貂病毒性肠炎（ＭＶＥ）细胞培养灭活矿油苗和铝胶苗接种于４８只水貂、１２只豚鼠、１２只家兔，检测三种动物免疫后６～４０天的血清ＨＩ抗体水平和水貂免疫后１１～３１天的ＳＮＩ，结果表明:（１）该两苗对水貂的体液免疫效力相同；（２）豚鼠、家兔、水貂接种疫苗后６～４０天的Ｈｌ抗体水平差异不显著，故豚鼠或家兔可作为水貂免后产生抗体水平的模型；（３）水貂免疫后１１～３ｌ天的ＨＩ抗体水平和ＳＮＩ成显著秩相关，故水貂血清ＮＩ抗体水平是检定水貂肠炎病毒（ＭＥＶ）疫苗对水貂的体液免疫力的可靠指标。攻毒试验（２９只水貂）和扩大区域试验（８００多万只份疫苗:）结果证明，水貂免疫后的血清ＨＩ抗体水平、ＳＮＩ和免疫保护力均呈完全正相关。所以，豚鼠或家兔接种疫苗后ｌｌ～４０天的ＨＩ抗体水平是检定ＭＥＶ疫苗对水貂的体液免疫效力和免疫保护力的可靠指标，这就为大批量生产ＭＥＶ疫苗的免疫效力检定提供了经济、简便、可靠的检测指标和实验动物模型。
Orthogonal and paired experimental design, mink virus enteritis (MVE) cell culture inactivated mineral oil seedlings and aluminum seedlings inoculated in 48 minks, 12 guinea pigs, 12 rabbits, three animals tested after immunization 6 ~ 40 days of serum HI antibody levels and mink 11 to 31 days after immunization SNI, the results showed that: (1) the two strains of mink humoral immune efficacy of the same; (2) guinea pigs, rabbits, mink after vaccination 6 to 40 (3) The level of HI antibody in 11-3l days after mink immunization was significantly correlated with SNI, so the level of NIH antibody in mink serum was significantly lower than that in control group Antibody levels are reliable indicators of humoral immunity to mink enterococcal enteritis virus (MEV) vaccine. Toxicity tests (29 minks) and extended regional trials (over 8 million vaccines :) The results demonstrate a completely positive correlation between serum HI antibody levels, SNI and immunoprotective power after mink immunization. Therefore, the level of HI antibody in guinea pigs or rabbits 11 to 40 days after vaccination is a reliable indicator of the humoral and immuno-protective potency of MEV vaccine against mink, which provides an economic measure of immunity for mass-produced MEV vaccines , Simple and reliable test indicators and experimental animal models.