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目的探讨吲达帕胺联合氨氯地平治疗高血压合并冠状动脉粥样硬化性心脏病(CHD)患者的临床效果。方法选取2013年4月至2015年4月营口经济技术开发区第二人民医院收治的108例高血压合并CHD患者作为研究对象,采用随机数字表法将患者分为试验组与对照组,各54例。对照组患者给予硝苯地平控释片,试验组患者采用氨氯地平联合吲达帕胺进行治疗,比较两组患者的临床疗效、血压及血脂变化情况、不良反应发生情况。结果试验组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,试验组患者的三酰甘油、总胆固醇、收缩压、舒张压水平均明显低于对照组,差异均有统计学意义(均P<0.05);试验组患者的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论吲达帕胺与氨氯地平联合治疗高血压合并CHD临床效果显著,能有效改善患者血压、血脂水平,且不良反应发生率低,安全性高。
Objective To investigate the clinical efficacy of indapamide combined with amlodipine in the treatment of patients with hypertension and coronary heart disease (CHD). Methods From April 2013 to April 2015, 108 cases of hypertensive patients complicated with CHD were enrolled in the Second People’s Hospital of Yingkou Economic and Technological Development Zone. The patients were divided into experimental group and control group by random number table example. Patients in the control group were given nifedipine controlled release tablets. Patients in the test group were treated with amlodipine plus indapamide. The clinical efficacy, blood pressure, blood lipids and adverse reactions were compared between the two groups. Results The total effective rate of treatment group was significantly higher than that of the control group (P <0.05). After treatment, the triglyceride, total cholesterol, systolic blood pressure and diastolic blood pressure of the experimental group were significantly lower than those of the control group (P <0.05). The incidence of adverse reactions in the experimental group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion The combination of indapamide and amlodipine in the treatment of hypertension complicated by CHD has a significant clinical effect, which can effectively improve the blood pressure and blood lipid level of patients with low incidence of adverse reactions and high safety.