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目的本文观察初诊2型糖尿病给予甘精胰岛素联合阿卡波糖治疗前后血糖,糖化血红蛋白,胰岛β细胞功能的变化。方法选择31例初诊2型糖尿病(T2DM)给予甘精胰岛素(Glargine)治疗,如餐后血糖不达标加服阿卡波糖,治疗三个月。结果治疗后空腹血糖(FPG),餐后2h血糖,糖化血红蛋白(GHbAlc)均较前明显下降,空腹C肽较前升高(P<0.01),无低血糖发生。结论初发2型糖尿病给以甘精胰岛素联合阿卡波糖可有效控制血糖,使血糖平稳达标,胰岛β细胞功能改善。
Objective To observe the changes of blood glucose, glycosylated hemoglobin and pancreatic β-cell function in newly diagnosed type 2 diabetic patients before and after treatment with glargine and acarbose. Methods 31 cases of newly diagnosed type 2 diabetes mellitus (T2DM) were given Glargine treatment, such as postprandial blood glucose non-compliance plus acarbose treatment for three months. Results Fasting plasma glucose (FPG), 2h postprandial blood glucose and GHbAlc were significantly decreased compared with those before treatment, while fasting C peptide was higher than before (P <0.01). No hypoglycemia occurred. Conclusion Initial type 2 diabetes mellitus with insulin glargine combined with acarbose can be effective in controlling blood glucose, blood glucose reached a standard, pancreatic β-cell function improved.