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本文报告致死量精神药物中毒时的血药浓度监测方法及其病人体内的代谢动力学过程。结果表明,氯丙嗪、安眠酮、安定、多虑平等药物在超大剂量时仍按线性动力学过程代谢与消除。其中安定与氯丙嗪经肝脏代谢后以原型和多种代谢物从尿中排泄。而安眠酮与多虑平则主要以原型从尿中排出,安定从腹膜透析液中透出率较高。此外,安定与安眠酮均存在双峰现象,因此抢救过程中应进行连续血浓度监测。
This article reports the method of monitoring plasma concentrations of lethal psychotropic drugs and their in vivo pharmacokinetic processes. The results showed that chlorpromazine, methaqualone, diazepam, doxepin and other drugs in the super-dose according to the linear kinetic process of metabolism and elimination. Among them, diazepam and chlorpromazine are metabolized by the liver and excreted from the urine with prototypes and various metabolites. And sleeping ketone and doxepin are mainly prototyped excreted from the urine, diazepam from peritoneal dialysis fluid penetration rate higher. In addition, stability and methamphetamine both exist double peak phenomenon, so the rescue process should be continuous blood concentration monitoring.