论文部分内容阅读
多数传染病已成功地应用皮内接种获得免疫,这种途径十分经济,仅是皮下、肌内注射所需剂量的1/10。目前乙肝疫苗一个常规免疫程序需花费50～100元不等,而许多第三世界国家对这免疫又是十分需要的。乙肝疫苗在成人皮内注射的成功试验已有报导,但抗体水平不如肌注那样高,而乙肝疫苗在儿童皮内注射的应用尚无报导。本文报导了应用不同的免疫程序于冈比亚儿童皮内注射乙肝疫苗的三次试验结果。第一组试验把1μg(50ul)乙肝(HBV)血浆疫苗与50μg(50μl)卡介苗(BCG)
Most infectious diseases have been successfully vaccinated with intradermal vaccination. This approach is very economical and is only 1/10 of the dose required for subcutaneous, intramuscular injection. At present, a routine immunization program for hepatitis B vaccine will cost from 50 to 100 yuan, and many third world countries are in great need of this immunity. Successful trials of intrahepatic injections of hepatitis B vaccine have been reported, but antibody levels are not as high as those of intramuscular injection, and the use of hepatitis B vaccine in children for intradermal injection has not been reported. This paper reports the results of three trials of intradermal hepatitis B vaccine in Gambian children using different immunization protocols. The first set of experiments combined 1 μg (50 ul) of Hepatitis B (HBV) plasma vaccine with 50 μg (50 μl) of BCG