论文部分内容阅读
目的探讨乙型肝炎病毒（ＨＢＶ）感染与消化性溃疡（ＰＵ）之间的关系及其在ＰＵ形成中的作用机制．方法１９８９１０／１９９５０９因消化道症状而进行内镜检查及血清ＨＢＶＭ检测的３３４例患者，并对结果进行统计学处理分析．结果在３３４例患者中有４６例感染了ＨＢＶ，列为ＨＢＶ感染组，检出ＰＵ１９例（４１３％），其余２８８例列为ＨＢＶ非感染组，检出ＰＵ６６例（２２９％），两组有极显著差异（Ｐ＜００１）．在３３４例患者中有ＰＵ８５例，列为ＰＵ组，血清ＨＢＶＭ阳性率为２２４％，其中胃溃疡（ＧＵ）３１例（３６５％），十二指肠溃疡（ＤＵ）３５例（４１２％），复合性溃疡（ＣＵ）１９例（２２３％），ＧＵ，ＤＵ及ＣＵ血清ＨＢＶＭ阳性率分别为２５８％（８／３１），２２９％（８／３５）及１５８％（３／１９），三组相互间比较无显著性差异（Ｐ＞００５）；其余２４９例列为非ＰＵ组，血清ＨＢＶＭ阳性率１０８％，两组有极显著差异（Ｐ＜００１）．ＰＵ组与全国城市人群标化ＨＢＶＭ阳性率７９％比较有极显著差异（Ｐ＜００１）．结论ＨＢＶ感染与ＰＵ关系密切，是参与ＰＵ发病的一个因素．
Objective To investigate the relationship between hepatitis B virus (HBV) infection and peptic ulcer (PU) and its mechanism in PU formation. Methods 1989 10/1995 09 due to gastrointestinal symptoms and endoscopy and serum HBV M detection of 334 patients, and the results were statistically analyzed. Results Of the 334 patients, 46 were infected with HBV and were classified as HBV infection group. 19 cases (41.3%) were detected as PU and the remaining 288 cases were classified as HBV non-infected group. PU66 cases (22.9%) were detected, , There was a significant difference between the two groups (P <001). There were PU85 cases in 334 cases, which were classified as PU group, the positive rate of serum HBVM was 224%, including 31 cases (365%) of gastric ulcer (GU), 35 cases of duodenal ulcer The positive rates of HBVM in serum of GU, DU and CU were 258% (8/31) and 229% respectively in the cases (412%), 19 cases (223%) of complex ulcer (CU) (8/35) and 158% (3/19) respectively. There was no significant difference among the three groups (P> 005). The remaining 249 cases were classified as non-PU group. The positive rate of serum HBVM was 10 8%, there was a significant difference between the two groups (P <001). PU group and the national urban population standardized HBVM positive rate of 79% compared to have a very significant difference (P <001). Conclusion HBV infection is closely related to PU and is a factor involved in the pathogenesis of PU.