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目的:观察急性重型胰腺炎急性肺损伤动物模型肺泡巨噬细胞计数、活性、分泌炎性细胞因子功能变化及药物对其影响。方法:制备大鼠重型胰腺炎模型,采取肺泡巨噬细胞做各项指标检测及病理学检查。结果:模型组病理表现为明显的肺损伤,大承气汤治疗效果最显著。模型组肺泡巨噬细胞计数、活性、分泌炎性细胞因子显著高于对照组(P<0-01) ,各治疗组显著低于模型组( P< 0-01) ,善得定抑制巨噬细胞分泌炎性细胞因子作用最强,大承气汤抑制巨噬细胞数量较显著。结论:肺泡巨噬细胞过度活化,过度分泌炎性细胞因子是重型急性胰腺炎急性肺损伤发病的重要原因之一。中药能控制过度的炎性反应状态,对受损伤的肺组织细胞具有保护作用
Objective: To observe the changes of alveolar macrophage counts, activities, and secretion of inflammatory cytokines in acute lung injury induced by acute pancreatitis in rats and their effects on drugs. METHODS: A rat model of severe pancreatitis was prepared, and alveolar macrophages were taken for each index detection and pathological examination. Results: The pathological manifestations of the model group were obvious lung injury. The treatment effect of Dachengqi Decoction was the most significant. The alveolar macrophage count, activity, and inflammatory cytokines in the model group were significantly higher than those in the control group (P<0-01), and significantly lower in the treatment groups than in the model group (P<0-01). The secretion of inflammatory cytokines is the strongest in cells, and Dachengqi Decoction has a significant inhibition of the number of macrophages. Conclusion: Over-activation of alveolar macrophages, excessive secretion of inflammatory cytokines is one of the important causes of acute lung injury in patients with severe acute pancreatitis. Chinese medicine can control excessive inflammatory reaction state and protect the injured lung tissue cells