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应用双抗体夹心酶联免疫吸附测定法(ELISA)和氚标记胸苷(~3H-TdR)掺入法分别对128例鼻腔鼻咽良、恶性肿瘤患者外周血白细胞介素2(IL-2)和可溶性IL-2受体(sIL-2R)进行测定,并于鼻咽癌放疗前后作动态检测。结果表明:鼻腔良性肿瘤患者的sIL-2R水平与正常人接近(P>0.05);鼻腔鼻咽中线T细胞恶性淋巴瘤与鼻咽癌患者sIL-2R水平明显高于正常人和良性肿瘤患者,(均P<0.001);成人腺样体肥大和重度慢性鼻咽炎患者sIL-2R水平也显著高于正常人,但明显低于鼻咽癌患者(均P<0.0005);鼻咽癌患者sIL-2R水平于放疗结束、放疗后3月及6月逐渐下降,6月后预后良好者水平接近正常,复发和(或)转移者又明显升高。而IL-2水平变化则正好与sIL-2R变化相反,IL-2与sIL-2R呈明显负相关(r=-0.516,P<0.01)。提示IL-2和sIL-2R似可作为判断鼻咽癌预后的重要指标,对sIL-2R升高的成人腺样体肥大和慢性鼻咽炎患者应进行追踪观察。
The levels of interleukin 2 (IL-2) in 128 patients with benign and malignant nasal cavity nasal pharynx were determined by enzyme-linked immunosorbent assay (ELISA) and tritiated thymidine incorporation (3H-TdR) And soluble IL-2 receptor (sIL-2R) were measured before and after radiotherapy for nasopharyngeal carcinoma for dynamic detection. The results showed that the level of sIL-2R in patients with nasal benign tumors was similar to that in normal subjects (P> 0.05). The levels of sIL-2R in nasopharyngeal midline T-cell lymphoma and nasopharyngeal carcinoma were significantly higher than those in normal and benign tumors, (All P <0.001). The levels of sIL-2R in adult patients with adenoid hypertrophy and severe chronic nasopharyngitis were significantly higher than those in normal people, but significantly lower than those in patients with nasopharyngeal carcinoma (all P <0.0005) 2R levels at the end of radiotherapy, gradually decreased in March and June after radiotherapy, and after 6 months, the prognosis of patients with good prognosis was close to normal, and the recurrence and / or metastasis was significantly elevated. IL-2 and sIL-2R had a negative correlation (r = -0.516, P <0.01), while IL-2 level was just opposite to that of sIL-2R. These results suggest that IL-2 and sIL-2R may be used as important prognostic indicators for NPC, and should be followed up in adults with adenoid hypertrophy and chronic nasopharyngitis with elevated sIL-2R.