论文部分内容阅读
目的:考察高渗氯化钠羟乙基淀粉40注射液(HSS40)抗休克作用的剂量范围,并对其临床疗效和安全性进行初步观察.方法:以失血性休克患者为受试对象,观察静脉滴注HSS40后受试者血压变化和实验室检查指标的变化。结果:应用HSS40在500ml范围内可迅速升高血压,有效率为100％.;部分受试者血氯、血钠水平有一过性升高,给药后24小时恢复正常结论:HSS40在剂量为80ml～500ml范围内,安全有效,推荐临床用药剂量为300ml～500ml
OBJECTIVE: To investigate the anti-shock dose range of hypertonic sodium chloride hydroxyethyl starch 40 injection (HSS40) and to observe its clinical efficacy and safety.Methods: Hemorrhagic shock patients were observed, Changes of blood pressure and laboratory indexes of subjects after intravenous infusion of HSS40. Results: In the range of 500ml, HSS40 was used to rapidly increase blood pressure with an effective rate of 100%. Some subjects had a transient increase in blood chlorine and serum sodium levels and returned to normal 24 hours after administration. Conclusion: 80ml ~ 500ml range, safe and effective, recommended clinical dose of 300ml ~ 500ml