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采用免疫组织化学ABC法比较NGF ,BDNF在成年大鼠大脑皮质的分布 .结果 ,NGF ,BDNF样免疫阳性反应物均见于大鼠大脑皮质第 3,5层的锥体细胞 .NGF者主要分布于第三层 ,第五层相对少 .阳性反应物位于核周质 ,而BDNF者主要分布于第五层 ,除神经元胞体染色外 ,主树突亦有明显阳性反应 ,但两者各有侧重 .结果表明 ,在大脑皮质存在NGF ,BDNF ,但两者的分布有差异 ,提示NGF ,BDNF可能通过不同的方式参与大脑皮层锥体细胞的生理功能
Immunohistochemical ABC method was used to compare the distribution of NGF and BDNF in the cerebral cortex of adult rats.Results NGF and BDNF-like immunoreactive reactants were found in the pyramidal cells in the third and fifth layers of rat cerebral cortex.NGF were mainly distributed in the The third layer, the fifth layer is relatively less positive reactants in the perinuclear, and BDNF were mainly distributed in the fifth floor, in addition to neuronal cell staining, the main dendrites also have a significant positive reaction, but both have their own focus The results showed that there were NGF and BDNF in the cerebral cortex, but there was a difference in their distribution, suggesting that NGF and BDNF may participate in the physiological functions of cerebral cortex pyramidal cells in different ways